+ Physician Assistant Led · Pineville, NC

A primary care practice that does real medicine.

Family medicine and same-day visits first — alongside medical weight loss, hormone replacement, peptide and IV therapy run on labs, examination and follow-up. Not a med spa with a prescription pad.

Request an appointment ☎704-227-5060
Shawn O'Keefe, PA-C, founder of Twenty-One Medical, in a white coat
20+

years of medical experience

Request a visit in about a minute Confirmed by the office by email
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Same day
acute visits and IV therapy, when the schedule allows
5–100+
ages treated, from school physicals to hormone therapy
1
clinic instead of four — primary, same-day, ortho and wellness
2
states covered by telehealth, North and South Carolina

Primary care first.

This is a family medicine practice that keeps same-day availability — the wellness programs sit alongside it, with the same provider and the same chart.

Family medicineDiabetes, hypertension, routine physicals, STD testing, PAP smears and lab services.
Same-day careMinor wounds, sick visits, flu, strep, UTI and ear infections. Often available the same day.
OrthopedicsSprains, fractures, joint injections, X-ray and casting, with same-day evaluation.
DOT physicalsCertified exams for commercial drivers, usually same week.
See the clinical services
The wellness side

The programs people come to us for.

Every one of these is medically supervised, starts with labs, and includes the follow-up that makes it actually work.

A person in workout clothes with a towel over one shoulder, after exercising

Medical Weight Loss

Exam, labs and GLP-1 therapy with semaglutide or tirzepatide, plus the monthly visits that keep it on track.

See the program →
In-house lab area at Twenty-One Medical

Hormone Replacement

Men's and women's HRT, including EvexiPEL pellets placed in-house. Full hormone panel first, monitoring throughout.

See the program →
Clinical station at Twenty-One Medical

Peptide Therapy

Medically supervised peptide therapy built around a comprehensive exam, lab work and a plan written for you.

See the program →
An intravenous drip bag and line hanging from a stand in a treatment room

IV Therapy

Hydration, immune, energy, recovery and beauty drips — mixed and run by the clinical team in 45 to 60 minutes.

See the drip menu →
Aesthetic treatment room at Twenty-One Medical

Aesthetics

Botox, laser hair removal, skin rejuvenation and non-surgical body contouring on medical-grade equipment, under medical supervision.

See treatments →
Entrance to Twenty-One Medical, Suite 100
Meet your provider

Twenty years of medicine, in one clinic.

Shawn O'Keefe, PA-C has spent nearly five years in primary care at this practice. Before opening it he ran a surgical contracting company, first-assisting in the operating room across orthopedics, general surgery and OBGYN.

That range is why the wellness side here runs on labs, examination and follow-up rather than a questionnaire and a prescription — and why one clinic can cover a child's sports physical, a DOT exam, a torn meniscus and a hormone program without sending you anywhere else.

Primary careOrthopedics & sports medicineSame-day careTelehealth NC & SC
More about Shawn
Find us

Find us on Carolina Place Parkway.

Minutes from Ballantyne, Fort Mill and south Charlotte.

The Twenty-One Medical building on Carolina Place Parkway, Pineville NC
Address

11940 Carolina Place Parkway, Suite 100
Pineville, NC 28134

Phone

704-227-5060

Hours

Mon–Fri 8:30–5
Sat by appointment only
Labs Fri 9–12
Full hours & directions

Same-day care

Acute visits and IV therapy, subject to the schedule

Inside the clinic

Where you'll actually be seen.

Reception, exam rooms, the in-house lab and the treatment rooms — all in Suite 100, under one roof and one chart.

The reception area at Twenty-One Medical
Reception
An exam room at Twenty-One Medical
Exam room
The in-house lab at Twenty-One Medical
In-house lab
The aesthetic treatment room at Twenty-One Medical
Treatment room

Book with the provider you'll actually see.

Same-day availability for acute visits and IV therapy. Telehealth for North and South Carolina.

Request an appointment Call 704-227-5060